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TOPOTECAN-D6

Product Name
TOPOTECAN-D6
CAS No.
1044904-10-0
Chemical Name
TOPOTECAN-D6
Synonyms
Hycamtin-d6;TOPOTECAN-D6;NSC-609669-d6;SKF-104864A-d6;[2H6]-Topotecan;Topotecan dihydrochloride salt;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CBNumber
CB0649948
Molecular Formula
C23H23N3O5
Formula Weight
421.45
MOL File
1044904-10-0.mol
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TOPOTECAN-D6 Property

Melting point:
213-218°C (dec)
storage temp. 
-20°C Freezer
solubility 
aqueous acid: soluble; DMSO: slightly; Methanol: soluble
form 
A solid
Stability:
Hygroscopic
CAS DataBase Reference
1044904-10-0
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29082
Product name
Topotecan-d6
Packaging
500μg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
29082
Product name
Topotecan-d6
Packaging
1mg
Price
$299
Updated
2024/03/01
Usbiological
Product number
T8067-11
Product name
Topotecan-d6
Packaging
1mg
Price
$460
Updated
2021/12/16
TRC
Product number
T542502
Product name
Topotecan-d6
Packaging
10mg
Price
$1455
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0005320
Product name
TOPOTECAN-D6
Purity
95.00%
Packaging
100MG
Price
$1871.1
Updated
2021/12/16
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TOPOTECAN-D6 Chemical Properties,Usage,Production

Description

Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer.

Chemical Properties

Light Yellow to Greenish Powder

Uses

Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic

Uses

Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.

TOPOTECAN-D6 Preparation Products And Raw materials

Raw materials

Preparation Products

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TOPOTECAN-D6 Suppliers

Canada 2 China 17 France 1 India 1 United States 4 Global 25

1044904-10-0, TOPOTECAN-D6Related Search:

Topotecan Carboxylic Acid Sodium Salt Topotecan

  • TOPOTECAN-D6
  • (4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • SKF-104864A-d6
  • (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • Hycamtin-d6
  • NSC-609669-d6
  • (4S)-10-[[Di(methyl-d<sub>3</sub>)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • [2H6]-Topotecan
  • Topotecan dihydrochloride salt
  • 1044904-10-0
  • C23H17D6N3O5
  • C23H17N3O5D6
  • Heterocycles
  • Isotope Labelled Compounds
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Pharmaceuticals